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Abstract

The Expression of Pro-Platelet Basic Protein and Transcription Factor Activating Enhancer Binding Protein 4 Genes in Non-Small Cell Lung Cancer and Prognostic Value

Author(s): Rong Chen, Ya Hui Shen, Ai Gui Jiang, Gui Hong Dai, Xiao Yan Gao and Hui Yu Lu*
Department of Respiratory and Critical Care Medicine, 1Department of Pathology, Taizhou People's Hospital of Jiangsu Province, No. 366 Taihu Road, Taizhou, Jiangsu 225300, China

Correspondence Address:
Hui Yu Lu, Department of Pathology, Taizhou People's Hospital of Jiangsu Province, No. 366 Taihu Road, Taizhou, Jiangsu 225300, China, E-mail: [email protected]


To analyze the expression of pro-platelet basic protein and transcription factor activating enhancer binding protein 4 genes in non-small cell lung cancer and the prognostic value. 94 patients with non-small cell lung cancer undergoing lung cancer resection in our hospital from January 2015 to January 2016 were selected as study subjects and pro-platelet basic protein and transcription factor activating enhancer binding protein 4 messenger RNA expressions in cancer tissues and paracancerous tissues were detected by immunohistochemistry and other methods. The relationship between different levels of pro-platelet basic protein and transcription factor activating enhancer binding protein 4 messenger RNA expression levels and clinicopathological characteristics of patients was analyzed using Kaplan-Meier curves, used for survival analysis. Transcription factor activating enhancer binding protein 4 was lower in non-small cell lung cancer tissues than in paraneoplastic tissues (p<0.05) and the relative expression of pro-platelet basic protein was higher in all tissues than in paraneoplastic tissues (p<0.05). There were statistically significant differences in the maximum tumour diameter, tumor (T), nodes (N) and metastases (M) stage, proportion of lymph node metastasis and differentiation degree in the transcription factor activating enhancer binding protein 4 messenger RNA high expression group compared with the low expression group (p<0.05). The differences in maximum tumor diameter, tumor (T), nodes (N) and metastases (M) stage, proportion of lymph node metastasis and degree of differentiation were statistically significant in the pro-platelet basic protein messenger RNA high expression group compared with the low expression group (p<0.05). Survival analysis showed that the 5 y survival rate of the transcription factor activating enhancer binding protein 4 low expression group was higher than that of high expression group (p=0.028) and the 5 y survival rate of the pro-platelet basic protein high expression group was higher than that of low expression group (p=0.002). The expression of proplatelet basic protein and transcription factor activating enhancer binding protein 4 genes in cancer tissues of non-small cell lung cancer patients was significantly correlated with tumor (T), nodes (N) and metastases (M) stage, lymph node metastasis, maximum tumor diameter and differentiation degree, which could affect patients prognosis.

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