Abstract

To determine the level of bone metabolism indexes in patients with chronic obstructive pulmonary disease and its clinical significance. A total of 164 patients with chronic obstructive pulmonary disease admitted to the outpatient and inpatient departments of our hospital from April 2019 to April 2020 were selected as the study objects. Patients were divided into acute exacerbation group (n=78) and remission group (n=52) according to relevant criteria in chronic obstructive pulmonary disease. There was no significant difference in gender, age, body mass index and other general data among the three groups (p>0.05), showing comparability. The bone mineral density of femoral neck, lumbar spine and Ward’s triangle in the three groups had statistical significance (p<0.05). The bone metabolism indexes of beta-isomerized C-terminal telopeptides, procollagen type I N propeptide and osteocalcin in the acute exacerbation group were significantly higher than those in the remission group, the levels of 25-hydroxyvitamin D₃ in the acute exacerbation group were lower than those in the remission group and the differences had statistical significance (p<0.05). Pearson correlation analysis showed that bone mineral density of chronic obstructive pulmonary disease patients was negatively correlated with beta-isomerized C-terminal telopeptides, procollagen type I N propeptide, osteocalcin and positively correlated with 25-hydroxyvitamin D₃ (p<0.05). According to Pearson correlation analysis, there was a positive correlation between bone mineral density and 25-hydroxyvitamin D₃ in patients with chronic obstructive pulmonary disease (p<0.05), which was consistent. In conclusion, chronic obstructive pulmonary disease secondary osteoporosis is a high conversion type and bone mineral density and bone metabolism marker levels can effectively predict chronic obstructive pulmonary disease secondary osteoporosis.