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Abstract

The Regulatory Effect of D-Alloxan on Glucose Metabolism and Lipid Metabolism in Diabetic Mice

Author(s): Fengxia Cao, Tongxin Xia, E. Zhou and Jue Lin*
Department of Internal Medicine, The First Affiliated Hospital of Jiangxi Medical College, 1Department of Endocrinology, 2Department of Nephrology, Shangrao Municipal Hospital, 3Department of Endocrinology, Shangrao People's Hospital, Shangrao, Jiangxi Province 334000, China

Correspondence Address:
Jue Lin, Department of Endocrinology, Shangrao People's Hospital, Shangrao, Jiangxi Province 334000, China, E-mail: [email protected]


To investigate the regulatory effect of d-alloxan on glucose metabolism and lipid metabolism in diabetic mice. Twenty five mice were divided into control group, glucose group, fructose group, d-alloxan group and cellulose group. The results showed that the blood glucose of mice in each group reached the peak at 90 min and the blood glucose concentration of d-alloxan group was significantly lower than that of other groups (p<0.05). The blood glucose concentration of fructose group was significantly higher than that of other groups (p<0.05). The blood glucose concentration before and after meal in d-alloxan group was significantly lower than that in other groups (p<0.05), the liver glycogen concentration before and after meal was significantly higher than that in other groups (p<0.05), the insulin level was higher than that in other groups, but the difference was not significant (p>0.05), the muscle glycogen concentration before and after meal was not significant (p>0.05). The results showed that the triglyceride concentration of d-alloxan group was significantly lower than that of other groups (p<0.05). While it was not significantly lower than that of control group (p>0.05) and there was no significant difference in total cholesterol level between groups (p>0.05). The free fatty acid concentration in glucose group, fructose group and d-alloxan group was lower than that in control group and cellulose group (p<0.05). Compared with the control group, the low density lipoprotein concentration of the other four groups was significantly lower (p<0.05) and the low density lipoprotein concentration of the d-alloxan group was significantly lower than that of the other groups (p<0.05) and there was no significant difference between them (p>0.05). The results showed that the content of succinate dehydrogenase in the blood and tissues of d-alloxan group was significantly higher than that of other groups (p<0.05) and the level of hepatic lipase in d-alloxan group was higher than that of other groups, but there was no significant difference (p>0.05). Alloxan can effectively regulate blood glucose concentration, inhibit postprandial blood glucose rise, improve insulin level and liver glycogen level, but has no significant effect on muscle glycogen. It can be used as an ideal substitute of sucrose once the disorder of lipid metabolism is improved, the ability of fat metabolism is increased and antioxidation function is improved.

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