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Abstract

The Relationship of Weight-adjusted Bone Mass Content Associated with COPD and Associated Factors

Author(s): J. CHINDAPRASIRT1, W. BOONSAWAT2, P LIMPAWATTANA3*, D. THEERAKULPISUT4, M MANJAVONG3, K. SAWANYAWISUTH5, V CHOTMONGKOL6, P. INTHASUWAN1, S. PUTRAVEEPHONG1
1Division of Oncology Medicine, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Thailand, 2Division of Respiratory system, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Thailand, 3Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Thailand, 4Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Khon Kaen University, Thailand, 5Division of Ambulatory Medicine, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Thailand, 6Division of Neurology,

Correspondence Address:
Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Thailand, E-mail: [email protected]

The objectives of this study were to determine the distributions of weight-adjusted bone mass content and osteoporosis in chronic obstructive pulmonary disease patients, to examine the prevalence of osteoporosis and osteopenia and to determine factors associated with weight-adjusted bone mass content. A crosssectional study of chronic obstructive pulmonary disease patients at a tertiary-care hospital, Thailand was conducted from May 2015 to December 2016. Baseline characteristics were collected and bone mineral density and weight-adjusted bone mass content were measured using dual-energy X-ray absorptiometry. A total of 107 chronic obstructive pulmonary disease patients were included. The prevalence of osteoporosis and osteopenia were 35.5 and 38.2 %, respectively. The distribution of weight-adjusted bone mass content of arms, legs and whole body was significantly correlated with chronic obstructive pulmonary disease severity (p<0.05), but not with the presence of osteoporosis. Factors associated with weight-adjusted bone mass content of the extremities was the severity of chronic obstructive pulmonary disease (adjusted odds ratios of moderate and severe chronic obstructive pulmonary disease were 1.03 and 1.06), waist circumference (adjusted odds ratio 0.99) and appendicular skeletal mass index (adjusted odds ratio 0.98). Both osteoporosis and osteopenia were present in more than a third of the chronic obstructive pulmonary disease patients. The weight-adjusted bone mass content of arms, legs, extremities and whole body were correlated with the degree of airflow limitation but not the presence of osteoporosis. Factors associated with weight-adjusted bone mass content of the extremities were identified. Weight-adjusted bone mass content could be a good index to indicate the degree of bone loss in chronic obstructive pulmonary disease patients.

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