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Abstract

Therapeutic Efficacy of Xingnaojing Injection in Conjunction with Ginkgo biloba Extract in Managing Post-stroke Cognitive Impairment

Author(s): Zhongze Chen, H. Yu, Dan Ye and Zuoyan Liu*
Department of Rehabilitation Medicine, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, 1Key Laboratory of Rehabilitation Medicine in Sichuan Province, 2Community Health Service Center, Chengdu, Sichuan Province 610000, People's Republic of China

Correspondence Address:
Zuoyan Liu, Key Laboratory of Rehabilitation Medicine in Sichuan Province, 2Community Health Service Center, Chengdu, Sichuan Province 610000, People's Republic of China, E-mail: lzy18782248342@163.com


To assess the effectiveness of Xingnaojing injection in conjunction with Ginkgo biloba extract in managing post-stroke cognitive impairment. The period from June 2022 to June 2023 saw the treatment of 100 patients with post-stroke cognitive impairment at our hospital, all of whom were included in this study. The patients were then randomly assigned to an observation group (n=50) and a control group (n=50). While the control group was provided with intravenous infusion of Xingnaojing injection, the observation group, following the control group’s protocol, underwent treatment involving a combination of Xingnaojing injection and Ginkgo biloba extract injection. Both groups underwent therapy for a continuous 14 d period. During the treatment, the evaluation criteria encompassed the effectiveness of treatment, neural function (brain-derived neurotrophic factor, nerve growth factor), cognitive function (National Institute of Health Stroke Scale, activities of daily living, mini-mental state examination), neurotransmitter levels, and any unfavorable responses to the drugs. A notable distinction was observed, with the overall effective rate being significantly higher in the observation group (94.23 %) than in the control group (77.08 %). The incidence of adverse drug reactions showed no notable difference between the control and observation groups. Significant clinical effectiveness is evident in the treatment of poststroke cognitive impairment with the utilization of Xingnaojing injection in conjunction with Ginkgo biloba extract. It effectively enhances neural and cognitive function while ensuring safety for patients. The potential exists for this treatment approach to emerge as a key strategy in stroke rehabilitation and offer valuable insights for clinical treatment decisions. Nevertheless, additional extensive and prolonged follow-up studies are necessary to verify and reinforce these outcomes.

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