All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Transdermal Delivery Of Ampicillin Sodium Patch Made From Volatile Vehicle

Author(s): J Bagylakshmi, Sheheera Sheriff, Sonia John, T. K Ravi, P. K Manna, R Manavalan

The permeation of ampicillin sodium patch from ethanol/pH4.7 buffer solution containing antinucleant polymers across mouse skin, was investigated. The in vitro release of ampicillin sodium was determined under open condition at 25o and 65% relative humidity. Therefore the influence of evaporation of vehicle components on the permeation of ampicillin sodium was examined. Evaporation of the vehicle led to drastic compositional changes leading to supersaturation. However, supersaturation solutions started to crystallize reducing the thermodynamic activity of ampicillin sodium. Antinucleant polymers where used in the preparation of volatile vehicles in order to maintain the Increased activity state of the drug. Carboxymethylcellulose and hydroxypropylmethylcellulose were efficient antinucleant polymers to increase the permeation of ampicillin sodium.

PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report