Tyrosinase Inhibitory Effects of Sargachromanol G, Sargachromanol I and Mojabanchromanol b isolated from Myagropsis myagroides
Institute of Fisheries Sciences, Pukyong National University, Busan 46041, 1Department of Food Science and Technology/Institute of Food Science, Pukyong National University, Busan 48513, Republic of Korea
Department of Food Science and Technology/Institute of Food Science, Pukyong National University, Busan 48513, Republic of Korea, E-mail: firstname.lastname@example.org
The aim of this study was to elucidate the effect of Myagropsis myagroides extract on tyrosinase activity. Inhibition of tyrosinase was observed in the presence of an n-hexane fraction of Myagropsis myagroides. Separation of the n-hexane fraction using silica gel column chromatography yielded the chloroform:methanol (50:1) fraction, which showed the highest tyrosinase inhibitory activity. After several separation and purification steps, sargachromanol G, sargachromanol I, and mojabanchromanol b were obtained. These 3 chromene compounds displayed strong tyrosinase inhibitory activity. It could be concluded that Myagropsis myagroides is a potential source of natural antimelagenic compounds.