Abstract

Two simple and sensitive spectroscopic methods in ultraviolet and visible region were developed for the estimation of cefdinir in pharmaceutical dosage forms. In method A cefdinir showed absorption maximum at 287 nm in 0.1 M phosphate buffer (pH 7.0), whereas in method B, it reacted with Folin-Ciocalteu reagent under alkaline conditions forming a blue coloured chromogen having absorption maximum at 720 nm. These methods obey Beer's law in the concentration range of 3 to 17 μg/ml and 4 to 20 μg/ml, respectively. The methods are statistically evaluated for accuracy and precision.