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Abstract

Value of Serum Gastrin-17 Combined with Pepsinogen I, II and Helicobacter pylori C14 Detection in Early Diagnosis of Gastric Cancer

Author(s): Juan Wang, Min Sun, Xianyan Zhang*, Linyan Jiang and Ying Qin
Department of Gastroenterology, Health Management Center, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610017, China

Correspondence Address:
Xianyan Zhang, Department of Gastroenterology, Health Management Center, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610017, China, E-mail: xinghe2734946@163


To conduct a study on the value of serum gastrin-17 plus pepsinogen I, II and Helicobacter pylori C14 breath test in the early screening of gastric carcinoma. The clinical data of 96 patients with epigastric distress requiring gastroscopic pathological examination from January 2019 to June 2020 were analyzed retrospectively. 49 patients diagnosed with chronic superficial gastritis and chronic atrophic gastritis were included in the gastritis group, and 47 patients diagnosed with early gastric carcinoma were included in the gastric carcinoma group; the serum levels of gastrin-17, pepsinogen I, pepsinogen II, and pepsinogen ratio, as well as Helicobacter pylori positive rate, were compared between the two groups. The diagnostic value of various indicators and their combination was analyzed by the receiver operating characteristic curve. The patients in the gastric carcinoma group had a higher level of gastrin-17 than the gastritis group (p<0.05), whereas the patients in the gastric carcinoma group had a lower level of pepsinogen ratio than the gastritis group (p<0.05); for the early stage of gastric carcinoma, the diagnostic results of Helicobacter pylori positive, pepsinogen I, and pepsinogen II showed moderate consistency with the gold standard (p<0.05), the diagnostic results of serum gastrin-17 and pepsinogen ratio for the early stage of gastric carcinoma showed good consistency with the gold standard (p<0.05), and the diagnostic results of the combination of various indicators showed superior consistency with the gold standard (p<0.05); the positive rate of Helicobacter pylori detected by serum gastrin-17, pepsinogen I and pepsinogen II levels, pepsinogen ratio, and C14 breath test showed a moderate screening value for the early stage of gastric carcinoma (p<0.05), and the combination of various indicators embraced high screening value (p<0.05). Serum gastrin-17 combined with pepsinogen I, II, and Helicobacter pylori C14 shows a high application value for early screening of gastric carcinoma. Its advantage lies in convenient operation, good repeatability, and wide application. Moreover, it can provide a necessary reference for the screening and early diagnosis of gastric carcinoma.

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