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Visible Spectrophotometric Determination Of Levofloxacin In Tablet Dosage Forms

Author(s): Lakshmi Sivasubramanian, V Kasi Sankar, V Sivaraman, K Senthil Kumar, A Muthukumaran, T. K Raja

The present paper describes three simple, accurate, rapid and precise visible spectrophotometric methods for the estimation of levofloxacin in tablet formulations. Methods A and B were based on the formation of lon- association complex of the drug with Eriochrome black T and bromocresol green. The absorbance of chloroform extracted complexes was measured at 490 and 420 nm, respectively. Method C was based on the formation of blue coloured chromogen with Folin-Ciocalteau reagent which showed maximum absorbance at 720 nm. The optical characteristics and the statistical analysis for all the methods were satisfactory. Interference studies were carried out using common excipients and the percentage recovery of levofloxacin using method A, B and C was found to be 99.9, 101.6, 100.5 %, respectively.


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