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Visible Spectrophotometric Methods For The Estimation Of Loratadine From Tablets

Author(s): I Singhvi

Two visible spectrophotometric methods have been developed for estimation of loratadine from tablet formulation. These visible spectrophotometric methods are based on formation of chloroform extractable coloured complex of drug with cobalt thiocynate and bromophenol blue. The coloured complex formed with cobalt thiocynate showed absorbance maxima at 624.5 nm and linearity in the concentration range of 1.2-3.6 mg/ml of loratadine while the coloured complex formed with bromophenol blue showed absorbance maxima at 413 nm and linearity in the concentration range of 0-120 μg/ml of loratadine. Results of analysis for both the methods were validated statistically.


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