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Abstract

Wound healing activity of Lycopodium serratum

Author(s): BK Manjunatha1, V Krishna2, SM Vidya1, KL Mankani3, YN Manohara3
1 Department of Botany and Biotechnology, S. R. N. M. N. College of Applied Sciences, Shimoga - 577 201, India 2 Department of Biotechnology, Kuvempu University, Shankaraghatta - 577 451, India 3 Department of Pharmacology, National College of Pharmacy, Shimoga - 577 201, India

Correspondence Address:
B K Manjunatha Department of Botany and Biotechnology, S. R. N. M. N. College of Applied Sciences, Shimoga - 577 201 India E-mail: [email protected]


Wound healing activity of aqueous and ethanol leaf extracts of L. serratum was studied by excision, incision and dead space wound models on rats. As compared to aqueous and control group of animals, ethanol extract showed significant wound healing activity which was evidenced by significant decrease in the period of epithelialisation (17.84±0.06) and increase in wound contraction rate, skin breaking strength (581.45±4.98), granulation tissue breaking strength (512.80±5.08), dry weight of granulation tissue (47.23±0.10) and elevated concentration of hydroxyproline (2322.83±8.49). Histopathalogy of the granulation tissue of the ethanol extract treated animals showed few macrophages with increase in collagenation indicating the potency of the ethanol extract in promoting the process of wound healing. The present finding provides a scientific base to the ethno medicinal use of L. serratum.

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