Abstract
A series of anti-inflammatory 5-phenyl-3H-imidazo(4,5-c) (1,8) naphthyridin-4-(5H)-ones was subjected to quantitative structure activity relationship (QSAR) analysis. The QSAR study showed that the oral antiinflammatory activity, as determined in the carrageenan induced rat paw edema method was highly correlated with thermodynamic (MR) and electronic (Cedensity and Ncharge) parameters. The analysis suggests that lipophilic substituents at third position on the nitrogen atom which increase double bond conjugation within the molecule will enhance the biological activity.
