Abstract
A quantitative structure-activity relationship (QSAR) analysis of the binding activity data to the 5-HT1c and the 5-HT2 receptors for the congeneric series of phenylalkylamines was performed and the results there of revealed that the pharmacophoric requirements for both are nearly similar with only likely difference at 5- position of the phenyl ring. Further, for both subtypes, moderately hydrophobic substituent at 4-rign and less bulky groups at X are predicted to cause enhancement in potency of the ligand. A substituents at 2-ring appears to have synergistic influence.
