Abstract

The pandemic of coronavirus disease-19 involved various traditional medical formulations as therapeutics for treatment along with boosting the immunity to overcome the crisis. Thippili rasayanam was one among the medicines recommended by the Ministry of Ayurveda, Yoga, Unani, Siddha and Homoeopathy for coronavirus disease-19 in Siddha. In spite of the effectiveness, its role against the virus target was not clarified. As a consequence, the present docking study was performed to know its action against inhibition of the target enzyme ribonucleic acid-dependent ribonucleic acid polymerase. The phytocomponents of the herbs present in the formulation were retrieved through literature survey and in silico docking analysis was performed through Auto dock tool. The lead molecules were identified with respect to the target protein and the best dock pose was selected based on the molecular interaction. The phytocomponents epicatechin, myrcene, hyoscyamide, piperic acid, piperine and zingiberene, of the formulation Thippili rasayanam revealed maximum 3 interactions while betulonic acid, eucalyptol, galangin, p-thymol and ellagic acid showed 2 interactions with the active binding site of the target enzyme ribonucleic acid-dependent ribonucleic acid polymerase. Docking results suggest, the formulation Thippili rasayanam has potential inhibiting action against coronavirus disease-19 by reducing the viral replication.