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Abstract

GC-MS Analysis of Ethanol Extract of Taxithelium napalense (Schwaerg) Broth along with its alpha-Glucosidase Inhibitory Activity

Author(s): V. B. Tatipamula1*, K. N. Killari, K. V. Gopaiah1 and Alekhya Ketha
Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, 1K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur-522 502, India

Correspondence Address:
Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur-522 502, India, E-mail: [email protected]

Considering the antidiabetic potentiality of the moss Taxithelium napalense, the present study was undertaken to explore the chemical constituents that are present in this species. The entire moss Taxithelium napalense was extracted by ethanol and the extract obtained was subjected to gas chromatography-mass spectrometry. Sixty nine compounds were identified, which are reported for the first time from this species. From the gas chromatography-mass spectrometry analysis, it was determined that the octadecanoic acid methyl ester was the chief component present in Taxithelium napalense. In addition, the total phenolic and flavonoid contents of ethanol extract of Taxithelium napalense were found to be 101.43±0.38 mg Q/g and 229.73±3.07 mg GA/g, respectively. Additionally, the inhibitory concentration 50 of the ethanol extract of Taxithelium napalense on α-glucosidase was found to be 34.5 µg/ml, while acarbose value was 29.5 µg/ml. This is the first report on the chemical investigation of the moss Taxithelium napalense.