In vitro and in vivo advantage of celecoxib surface solid dispersion and dosage form development
Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai - 400 098, India
M S Nagarsenker Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai - 400 098 India E-mail: [email protected]
Celecoxib surface solid dispersions were prepared by various techniques using different ratios of drug and carriers. Infra-red spectroscopy and differential scanning calorimetry showed no significant change in solid state of celecoxib in the surface solid dispersions and physical mixtures of celecoxib and carriers. Surface solid dispersions exhibited superior dissolution profiles and improved antiinflammatory activity in rat paw oedema model. The increase in the dissolution rate and consequent enhancement of antiinflammatory effect in rats of celecoxib were attributed to reduced particle size of celecoxib deposited on the surface of carrier and enhanced wettability of the drug particles brought about by the carrier. Improved dissolution characteristics were retained when compressed into tablets.