Spectrophotometric determination of chlordiazepoxide and trifluoperazine hydrochloride from combined dosage form
Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492 010, India
R B Saudagar Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492 010 India E-mail: [email protected]
The present paper describes two simple, accurate, rapid, precise and economical procedures for simultaneous estimation of chlordiazepoxide and trifluoperazine hydrochloride in combined tablet dosage formulations. The first meth¬od is based on the multicomponent mode of analysis of the instrument used; the second method is developed on simultaneous equations. The Shimadzu 1700 pharmaspec UV/Vis spectrophotometer with a matched pair of 10 mm quartz cells was used for experimental purpose. Both the drugs obeyed Beer's law in the concentration range employed for the analysis. For all these methods 0.1 M HCl was used as a solvent. In this solvent system chlordiazepoxide showed maximum absorbance at a wavelength of 245 nm and trifluoperazine hydrochloride showed maximum absorbance at a wavelength of 255.5 nm. The results of analysis were validated statistically and by recovery studies.