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A comparative study of ethanol extract of leaves of Tephrosia purpurea pers and the flavonoid isolated for hepatoprotective activity

Author(s): A Jain, AK Singhai, VK Dixit
Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, India

Correspondence Address:
A Jain B. R. Nahata College of Pharmacy, Mandsaur - 458 001 India E-mail: [email protected]

Ethanol extract of leaves and flavonoid (isolated from leaves extract) from Tephrosia purpurea were evaluated for hepatoprotective activity in rats by inducing hepatotoxicity with carbon tetrachloride. These fractions were administered orally at a dose of 100 mg/kg/day. Serum level of transaminases, alkaline phosphate, and total bilirubin were used as biochemical markers of hepatotoxicity. Histopathological changes in the liver were also studied. The results of the study indicated that the hepatoprotective activity was more in ethanolic extract of leaves than isolated flavonoid.

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