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A Meta-Analysis of the Correlation between Cardiac Troponin I and the Prognosis of Sepsis

Author(s): Biqian Dong and Wanqiu Fan*
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Correspondence Address:
Wanqiu Fan, Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China, E-mail:

Adopt meta-analysis method to study the relationship between troponin I and prognosis of sepsis patients and to explore the predictive value of troponin I on prognosis of sepsis patients. In PubMed, EMBASE and Ovid MEDLINE, the clinical studies published as of September 2021 were comprehensively searched and screened through inclusion and exclusion criteria. The qualified clinical studies were incorporated to conduct quality evaluation and data extraction. Adopt RevMan 5.3 software for meta-analysis and evaluate the relationship between the troponin I level and indicators such as the mortality rate, length of hospital stay in patients with sepsis. The statistical results are represented by forest plots and the publication bias is tested by funnel plots. This research contains 14 independent studies and 3104 patients participated in the study. Meta-analysis results showed that compared with patients with sepsis in the troponin I-negative group; The mortality of patients in the troponin I positive group was significantly higher [odds ratio=2.21, 95 % confidence interval (1.88, 2.61), p<0.001]; No significant difference was found in incidence of septic shock in troponin I-positive group [odds ratio=1.32, 95 % confidence interval (0.65, 2.70), p=0.44]; It possessed no significant difference in length of hospital stay in troponin I-positive group [standardized mean difference=0.08, 95 % confidence interval] (-0.10, 0.25), p=0.39]. Compared with troponin I-negative sepsis patients, troponin I-positive sepsis patients have a higher fatality rate; however, the incidence of septic shock and the length of hospitalization between the two groups were not significantly different. Elevated troponin I has certain predictive value for prognosis of sepsis patients.

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