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A Quantitative Analysis Of N-Phenyl-6,11-Dihydrodibenzo[b,e]Oxepin-11-Carboxamides And Related Derivatives As The Inhibitors Of Acyl-CoA Cholesterol Acyl Transferase (ACAT)

Author(s): P Singh, R Kumar

The ACAT inhibitory activity, -log IC50 (molar), of N-phenyl-6,11-dihydrodibenzo[b,e]oxepin-11- carboxamides and related derivatives, has been quantitatively correlated with structural and electronic substituent parameters; the sum of molar refraction, ΣMR for the R1, the Kier's Δ parameter and a hydrogen bond count parameter, HB for 2-R2 and the sum of Δ parameters, ΣΔ’ for the 3-R2, R3, X, and Y-Z. The analysis has revealed that for good ACAT inhibitory activity, the substituent R1 should have a large MR value while 2-R2 should have a higher Δ but a lower HB. The remaining variations at 3-R2, R3, X, and Y-Z parts should be such that these give a lower ΣΔ' values.


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