Advances in Hypoxia-Inducible Factor 1-Alpha and Ischemic Heart Disease
Department of Cardiology, Wenzhou Central Hospital, The Second Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang 325000, 1Department of Translational Medicine, Institute of Translational Medicine, Shanghai University, Baoshan, Shanghai 200444, P. R. China
W. B. Jiang, Department of Cardiology, Wenzhou Central Hospital, The Second Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang 325000, P. R. China, E-mail: email@example.com
Ischemic heart disease, resulting from ischemic and anoxic cardiomyocytes, can lead to the abnormal metabolic activity which is able to result in some serious diseases including cardiac failure, thrombus and other deadly disease and it is also the bad factor to the health of human. Besides, oxidative stress resulting from ischemic heart disease is one of the most serious factors of this disease which can destroy the healthy tissue, protein and so on. Hypoxia, as a signal, is able to launch hypoxia-inducible factor 1-alpha which lives in cytoplasm. It transfers to cell nucleus to achieve its aim, which means hypoxia-inducible factor 1-alpha is going to bind to hypoxia-inducible factor 1-beta first, then start some downstream promoters to facilitate several target genes such as vascular endothelial growth factor, inducible nitric oxide synthase, necessary enzyme of glycolysis and erythropoietin. Reactive oxygen species has also been proved that, it can start hypoxia-inducible factor 1-alpha as the second messenger. At the moment, hypoxia-inducible factor 1-alpha has been proved that, it is influential for ischemic heart disease through some pathways such as the increased angiogenesis, promoting glycolysis and the decreased reactive oxygen species. In this review, we discussed the advances in hypoxiainducible factor 1-alpha and ischemic heart disease.