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Abstract

Anticholinesterase Activity and Mass Spectral Analysis of Olea dioica Roxb., An in vitro Study

Author(s): G. K. PRATAP, S. A. RATHER AND MANJULA SHANTARAM*
Department of Studies & Research in Biochemistry, Mangalore University, Jnana Kaveri Post Graduate Centre, Chikka Aluvara, Kodagu-571 232, 1Medical Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu and Kashmir-180 001, 2AcSIR-IIIM Jammu, Jammu and Kashmir-180 001, India

Correspondence Address:
2AcSIR-IIIM Jammu, Jammu and Kashmir-180 001, India, E-mail: [email protected]

The aim of the present study was to evaluate the total phenolic and flavonoid content, acetylcholinesterase inhibitory and antioxidant activity of Olea dioica. Some bioactive chemical constituents were characterized through GC-MS, LC-MS analyses. Methanol leaf extract of Olea dioica exhibited antioxidant property and acetylcholinesterase inhibition activity. Results showed that the plant extract could provide a significant source of secondary metabolites that could act as natural acetylcholinesterase inhibitors and antioxidants, which might be useful to treat Alzheimer's disease.

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