Abstract
Atypical Log D profile of rifampicin
Author(s): TT Mariappan, Nishi Sharda, Saranjit Singh
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Punjab - 160 062, India
Correspondence Address:
Saranjit Singh Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER),S.A.S. Nagar, Punjab - 160 062 India E-mail: ssingh@niper.ac.in
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Punjab - 160 062, India
Correspondence Address:
Saranjit Singh Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER),S.A.S. Nagar, Punjab - 160 062 India E-mail: ssingh@niper.ac.in
The distribution coefficient (log D) values of rifampicin, an essential first-line antitubercular drug, at gastrointestinal pH conditions are not reported in literature. Hence determinations were made using n-octanol and buffers ranging between pH 1-7. Also, log D values were predicted using Prolog D. Both the determinations showed opposite behaviour. The atypical experimental log D profile of rifampicin could be attributed to its surface-active properties, which also explained the reported permeability behaviour of the drug in various gastrointestinal tract segments.
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