Abstract

To investigate the clinical effects of tazarotene betamethasone cream combined with compounded allantoin cream in the treatment of chronic hand eczema. 95 patients with chronic hand eczema were randomly divided into a study group (n=48) and a control group (n=47). Study group received tazarotene betamethasone cream in combination with compounded allantoin cream and control group received tretinoin acetate 1 % cream in combination with compounded allantoin cream. The clinical efficacy, lesion degree score and pruritus score, incidence of adverse reactions and quality of life score of the two groups were compared. Study group had a higher treatment efficiency than control group (p<0.05). After treatment, study group had lower lesion extent score, pruritus score and dermatological life quality index than control group (p<0.05). There was no difference in the incidence of adverse reactions between the two groups (p<0.05). Tazarotene betamethasone cream combined with compounded allantoin cream is clinically effective and safe in the treatment of chronic hand eczema, and has a significant positive effect on the improvement of patients' quality of life.