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Clinical Efficacy of Non-Invasive Ventilator-Assisted Ventilation Combined with Morphine in the Treatment of Acute Heart Failure

Author(s): Mei Li, Enyan Yang, Xiangjing Kong and Qin Xu*
Emergency Department, 1Intensive Care Unit, 2Department of Nursing, 3Department of Cardiology and Nephrology, Eastern Theater Air Force Hospital, Nanjing, Jiangsu 210003, China

Correspondence Address:
Qin Xu, Department of Cardiology and Nephrology, Eastern Theater Air Force Hospital, Nanjing, Jiangsu 210003, China, E-mail:

To observe the clinical efficacy of the use of non-invasive ventilator assisted ventilation in combination had morphine in the treatment of patients had acute heart failure. The clinical data of 100 patient had acute heart failure in the department of cardiology of our hospital from 2020 to 2023 were retrospectively collected. They were divided into the experimental group and the control group according to whether morphine treatment was added to the treatment plan, in which the experimental group was treated had non-invasive ventilator-assisted ventilation combined had morphine treatment (n=50), the control group was treated with non-invasive ventilator-assisted ventilation treatment (n=50). Thus, to investigate the therapeutic effect of patient had acute heart failure; non-invasive ventilation had combined with morphine. No significant differences were found between baseline levels in either group, various pre-treatment clinical and heart function indicators (p>0.05). The therapeutic effect of patient in the experimental group was significantly better than that of patient in the control group (p<0.05), the frequency of adverse reactions in patient in the experimental group was lower than in the control group (p<0.05). Comparing the clinical indexes and cardiac function indexes of the two groups, it was found that the clinical indexes of the experimental group included systolic blood pressure, diastolic blood pressure, heart rate, respiration, mean airway pressure, and partial pressure of oxygen, partial pressure carbon dioxide, and oxygen saturation indexes of arterial blood gas analysis in the vital signs of the experimental group, the cardiac function indexes included left ventricular ejection fraction, left ventricular end-diastolic diameter, left ventricular end-diastolic dimension, left ventricular diameter, left ventricular mass index, B-type natriuretic peptide, NT-PP, and NT-PP in the echocardiogram and the heart failure markers of the experimental group, respectively. B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide index levels were better than those of control patient (p<0.05).Treatment of patient with acute heart failure had non-invasive ventilation in combination with morphine is more effective and safer.

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