Correlation Analysis between the Level of Coagulation Function and Osteonecrosis of Femoral Head
Clinical School of Yangzhou University, Yangzhou 225001, Jiangsu, 1Department of Orthopedics, Sihong People’s Hospital, Sihong 223900, Jiangsu Province, China
L. Yan, Clinical School of Yangzhou University, Yangzhou 225001, Jiangsu, China, E-mail: firstname.lastname@example.org
To explore the correlation analysis between the level of coagulation function and osteonecrosis of femoral head is the main objective of the study. Osteonecrosis of femoral head is the end point of the disease process due to inadequate blood flow and osteonecrosis of bone tissue, and later in the disease, femoral head collapse, arthritis or even hip replacement surgery may be required. Therefore, it is called avascular necrosis of femoral head and is a common and intractable disease in orthopedics clinic. According to statistics, there are about 7.5~10 million patients with osteonecrosis of femoral head in our country and the number of new cases is up to 300 000 every year. It is seen mostly in people aged 30-50 y and about half involve bilateral femoral heads. Its pathogenesis is influenced by many factors and complex mechanisms, and osteonecrosis of femoral head is most commonly caused by trauma, corticosteroid and alcohol use, but is also associated with blood metabolic disorders and coagulation disorders. To evaluate the relationship between prothrombin time, activated partial thromboplastin time, thrombin time and fibrinogen levels in patients with osteonecrosis of femoral head. Prothrombin time, activated partial thromboplastin time and fibrinogen levels were independent risk factors for the development of osteonecrosis of femoral head and all of them were risk factors; that is, the lower the prothrombin time and activated partial thromboplastin time levels, the higher the fibrinogen level and the higher the risk of osteonecrosis of femoral head occurrence.