Abstract
Determination of ambroxol hydrochloride using dithiocarbamic acid colorimetric method
Author(s): PNS Pai, N Lalitha, B Balakrishna, GK Rao
Department of Quality Assurance, Al-Ameen College of Pharmacy, Bangalore-560 027, India
Correspondence Address:
PNS Pai Department of Quality Assurance, Al-Ameen College of Pharmacy, Bangalore-560 027 India E-mail: pnsanjaypai@rediffmail.com
Department of Quality Assurance, Al-Ameen College of Pharmacy, Bangalore-560 027, India
Correspondence Address:
PNS Pai Department of Quality Assurance, Al-Ameen College of Pharmacy, Bangalore-560 027 India E-mail: pnsanjaypai@rediffmail.com
A new simple, colorimetric method was developed on the basis of a chemical reaction of amine group in ambroxol hydrochloride with carbon disulphide to form dithiocarbamic acid, which on further reaction with cupric chloride forms a colored copper chelate. The yellowish-orange chromophore has absorption maxima of 448 nm and obeys Beer's law in the concentration range of 10-100 µg/ml. Results of the analysis were statistically validated by recovery studies. The method was found to be suitable for routine determination of ambroxol hydrochloride in tablet formulation.
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