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Abstract

Determination of the Isoniazid N-Acetylation Phenotype in a Sample Indian Population

Author(s): Alice M. Varghese and K. R. Iyer*
Department of Pharmaceutical Chemistry, Bombay College of Pharmacy (Autonomous), Kalina, Mumbai 400 098, India

Correspondence Address:
K. R. Iyer, Department of Pharmaceutical Chemistry, Bombay College of Pharmacy (Autonomous), Kalina, Mumbai 400 098, India, E-mail: krishna.iyer@bcp.edu.in


An isoniazid N-acetylation phenotyping study was carried out in 200 human volunteers. A single urine sample taken 5 h post-isoniazid oral dose of 300 mg was analyzed and urinary concentrations of isoniazid and its metabolite acetylisoniazid were determined by high-performance liquid chromatography. Acetylator phenotype was determined from the metabolic ratio of N-acetylisoniazid to isoniazid concentration in the urine sample. The cut-off value, antimode, to distinguish between slow and fast acetylators was determined by probit analysis. Of the total 194 subjects phenotyped, 70.1 % were slow acetylators, 27.6 % were intermediate acetylators and 2.7 % were fast acetylators.

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