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Effect of permeation enhancers on the release and permeation kinetics of Lincomycin hydrochloride gel formulations through mouse skin

Author(s): L Panigrahi1, SK Ghosal2, Snigdha Pattnaik3, L Maharana3, BB Barik4
1 Sun Pharma Advance Rearch Center, Tandalja, Vadodara-390 020, India 2 Pharmaceutical Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Calcutta-700 032, India 3 School of Pharmaceutical Sciences, I. T. E. R., Jagamohan Nagar, Gagamara, Bhubaneswar-751 030, India 4 University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar-751 004, India

Correspondence Address:
L Panigrahi Sun Pharma Advance Rearch Center, Tandalja, Vadodara-390 020 India E-mail: [email protected]

Lincomycin hydrochloride is a systemic antibiotic, which is active against most common gram positive bacteria. It has proved to be excellent for infectious diseases like acne, anthrax, pneumonia, and also for the treatment of furunculosis, carbuncles, impetigo, burns and wounds, carrying to gram positive bacteria. Gels were prepared using carbopol 940 as gelling agent, and isopropyl myristate and dimethyl sulfoxide as permeation enhancer. The formulations were evaluated for drug content, viscosity, pH, extrudability, homogeneity, skin irritation test, spreadability, and gel strength. A formulation containing 1.5% carbopol with 10% isopropyl myristate, showed better in vitro skin permeation through abdominal mouse skin, and was found to be the best.

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