Abstract

To explore the effect of Qiwei Baizhu Powder on the intestinal flora of splenoasthenic diarrhea mice and its mechanism. The splenoasthenic diarrhea mouse model established by different modeling methods (antibiotics and traditional Chinese medicine compound prescription) was used as the experimental group, and a blank control group was set up at the same time. Qiwei Baizhu Powder was used to treat the splenoasthenic diarrhea model mice. The splenoasthenic diarrhea mouse model established by taking Dachenqi Tang (Traditional Chinese medicine Group) had the most severe splenoasthenic diarrhea and poor mental state, while without significant effect on intestinal flora (p>0.05). The splenoasthenic diarrhea mouse model constructed by gentamicin sulfate and cefradine (Antibiotic combination group) had the best effect. The results of the antimicrobial spectrum showed that the gentamicin sulfate and cefradine could form the maximum complementary effect and the effect was long-lasting. After the intragastric administration of Qiwei Baizhu Powder, the mice in the Traditional Chinese medicine Group were quickly cured and the syndrome of splenoasthenic diarrhea disappeared. The number of intestinal lactic acid bacteria and fungi in the antibiotic combination group was significantly higher than that in the normal group (p<0.01). In Qiwei Baizhu Powder, there are probiotics that promote the growth of lactic acid bacteria and fungi, which can cure the imbalance of intestinal flora.