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In Vitro Antioxidant, Hypolipidemic and Anti-Lipase Potential of Joha Rice of Assam, India

Author(s): R. Chakraborty, P. Kalita, P. Manoj Kumar and S. Sen*
Faculty of Pharmaceutical Science, Assam down town University, Guwahati, Assam 781026, 1Assam Don Bosco University Institute of Pharmacy, Assam Don Bosco University, Sonapur, Assam 782402, 2Pratiksha Institute of Pharmaceutical Sciences, Guwahati, Assam 781026, 3The Dale View College of Pharmacy and Research Centre, Thiruvananthapuram, Kerala 695575, India

Correspondence Address:
S. Sen, Faculty of Pharmaceutical Science, Assam down town University, Guwahati, Assam 781026, India, E-mail:

Present research accounts for in vitro antioxidant, hypolipidemic and pancreatic lipase inhibitory potential of two scented rice of Assam, India, namely ketoki joha and kola joha. Our result showed that ethanol extract of ketoki joha and kola joha (whole rice), particularly ketoki joha, exhibits a potent antioxidant potential when tested through DPPH•, NO•, H2O2 scavenging and lipid peroxidation inhibition assay. Among different whole rice extracts, ethanol extract of ketoki joha and kola joha at 100 μg/ml produced 76.67 % and 62.47 % inhibition of β-Hydroxy β-methylglutaryl-CoA reductase activity respectively. Ethanol and petroleum ether extracts potently inhibit cholesterol esterase. Ethyl acetate extract of ketoki joha showed the highest pancreatic lipase half maximal inhibitory concentration (IC50)= 254.28 μg/ml). In conclusion, the results showed that both rice varieties, mainly ketoki joha, possess potent antioxidant, β-Hydroxy β-methylglutaryl- CoA reductase, pancreatic lipase inhibitory effect, and cholesterol esterase inhibitory effect. Observations might suggest the role of whole joha rice in combating oxidative stress and obesity-related cardiovascular diseases, including atherosclerosis.

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