Abstract
In Vitro Evaluation of Antigenotoxic and Antioxidative Properties of Curcumin
Department of Clinical Pharmacy, Faculty of Pharmacy, 1Center for Genetics, Medical Faculty, 2Department of Natural Sciences, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne bb, Sarajevo 71000, Bosnia and Herzegovina
Correspondence Address:
B. Pehlivanović, Department of Clinical Pharmacy, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne bb, Sarajevo 71000, Bosnia and Herzegovina, E-mail: belma.pehlivanovic@ffsa.unsa.ba
Modern biomedical science has proven beneficial effects of curcumin as potential therapeutic candidate for various conditions due to its pleiotropic and pharmacological properties. The aim of the present study was to investigate antigenotoxic effects of curcumin against cisplatin induced genotoxicity as well as its antioxidative effects. In vitro cytokinesis block micronuclei assay in human lymphocytes was used for evaluation of antigenotoxic properties of curcumin. Evaluation of antioxidative properties of curcumin was determined with 2,2-Diphenyl-1-picrylhydrazyl free radical scavenging assay. Results demonstrated significant antigenotoxic and antioxidative properties of curcumin, dependent upon the tested concentrations. Consideration should be given to performing a study with broad dose interval of tested substances. Findings from the present study emphasized application of curcumin as potential antigenotoxic and antioxidative supplementary agent.
