In vivo Antinociceptive Effect of Methanolic Extract of Ipomoea marginata Desr. in Rodents as well as In silico Molecular Docking of Some Phytoconstituents from the Plant
Department of Chemistry, Gudlavalleru Engineering College, Gudlavalleru 521356, 1Pharmacognosy Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, 2Department of Pharmaceutical Analysis, Vallabhaneni Venkatadri Institute of Pharmaceutical Sciences, Gudlavalleru 521356, Andhra Pradesh, India
D S N B K Prasanth, Pharmacognosy Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, India, E-mail: firstname.lastname@example.org
This research was performed to analyze the antinociceptive task of methanolic extract of Ipomoea marginata in addition to in silico evaluation of the antinociceptive task of the separated constituents from Ipomoea marginata versus cyclooxygenase 2 enzyme together with absorption, distribution, metabolism, excretion/toxicity analysis of separated substances. In vivo antinociceptive task of methanolic extract of Ipomoea marginata was examined by acetic acid-induced agonizing, tail immersion and the hot plate on rodents. In silico activity of the isolated substances, absorption, distribution, metabolism, excretion/toxicity assessment was carried out by Autodock 4.0 and data warrior software applications. The results revealed that methanolic extract of Ipomoea marginata has the greatest possible dose-dependent antinociceptive task at all doses. Amongst the substances, Ipalbidine showed the very best docking score of -8.26, which was virtually better than standard diclofenac, i.e., -7.03, guaranteeing good binding compatibility among the ligand and the receptor than the standard and absorption, distribution, metabolism, excretion/toxicity evaluation using data warrior assures the compound has not breached Lipinski's guideline of five suggesting its safety consumption. To conclude, Ipomoea marginata can be a potent resource of antinociceptive activity and also additional simulation studies are needed to develop the performance of Ipalbidine.