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Evaluation of antimicrobial and wound healing potentials of ethanol extract of wedelia biflora linn D.C. leaves

Author(s): D Biswas1, GP Yoganandam2, A Dey3, L Deb3
1Sri Krupa Institute of Pharmaceutical Science, Velkatta, Kondapak, Medak 502 277, India 2Department of Pharmacognosy, Mother Theresa Post graduate and Research Institute of Health Science, India 3Pharmacology Laboratory, Institute of Bioresources and Sustainable Development (IBSD), India

Correspondence Address:
L Deb Pharmacology Laboratory, Institute of Bioresources and Sustainable Development (IBSD), Imphal-795 001 India E‑mail:

To rationalize scientifically the traditional claim on use of Wedelia biflora (Linn.) D. C. for the treatment of wounds and infections, the present study was designed to evaluate the antimicrobial and wound healing activity of ethanol extract of leaves of W. biflora. In in vitro assays the test extract was subjected to antimicrobial activity by agar well-diffusion method and minimum inhibitory concentration method in different microbial strains. Wound healing activity of the test extract was studied by excision wound model and incision wound model in Wistar albino rats. In excision wound model, 97.90% wound healing was recorded in 10% w/w extract treated group on 16 th days of postsurgery, whereas only 58.50% was observed in control group. In incision model, higher breaking strength, high hydroxyl proline content and histopathological study in extract treated groups revealed higher collagen redeposition than the control group. The agar well-diffusion evaluation and minimum inhibitory concentration established antimicrobial efficacy of ethanol extracts of W. biflora. These observations established the traditional claim and therapeutic activity of W. biflora and it could be a potent wound healing candidate for use in future.

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