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Evaluation of nanodispersion of iron oxides using various polymers

Author(s): Y Tanaka1, H Ueyama1, M Ogata1, T Daikoku1, M Morimoto1, A Kitagawa2, Y Imajo2, T Tahara2, M Inkyo2, N Yamaguchi3, S Nagata1
1Laboratory of Pharmaceutical Technology, Hiroshima International University, Hiroshima 7370112, Japan 2Kotobuki Industries Co., Ltd., Ohashi-Gyoen-Bldg. 2F, 1-8-1 Shinjuku, Shinjuku-ku, Tokyo 1600022, Japan 3Kishi Kasei Co., Ltd., 1-11-22 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 2360004, Japan

Correspondence Address:
S Nagata Laboratory of Pharmaceutical Technology, Hiroshima International University, Hiroshima 7370112 Japan E-mail:

In order to create Fe2O3 and Fe2O3Î?H2O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated. It was revealed that not only the solution viscosity but also the molecular length of the polymers and the surface tension of the particles affected the dispersibility of Fe 2 O 3 and Fe 2 O 3Î?H 2 O particles. Using the dispersing agents 7.5% hydroxypropylcellulose-SSL, 6.0% Pharmacoat 603, 5.0% and 6.5% Pharmacoat 904 and 7.0% Metolose SM-4, Fe2O3 nanoparticles were successfully fabricated by wet milling using Ultra Apex Mill. Fe2O3Î?H2O nanoparticles could also be produced using 5.0% hydroxypropylcellulose-SSL and 4.0 and 7.0% Pharmacoat 904. The index for dispersibility developed in this study appears to be an effective indicator of success in fabricating nanoparticles of iron oxides by wet milling using Ultra Apex Mill.

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