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Abstract

Evaluation of Wound healing and Antiinflammatory Activities of New Poly-herbal Formulations

Author(s): K. SOUJANYA, K. SRINIVAS REDDY, D. KUMARASWAMY, G. VISHWANATH REDDY, P. GIRIJA AND K. SIRISHA*
Departments of Pharmacology and Medicinal Chemistry, Vaagdevi College of Pharmacy, Kishanpura, Hanamkonda, Warangal, Telangana-506 001, India

Correspondence Address:
Departments of Pharmacology and Medicinal Chemistry, Vaagdevi College of Pharmacy, Kishanpura, Hanamkonda, Warangal, Telangana-506 001, India, E-mail: [email protected]


Present investigation evaluated the impact of poly-herbal formulations comprising extracts of Zingiberofficinale, Curcuma longa, Aloe barbadensis, Citrus aurantium, Emblica officinalis and castor oil on wound healing activity using excision wound model and antiinflammatory activity using formalininduced pawedema method. Ointments containing 2, 4 and 6 % w/w of extracts were made and used in wound healing action and all the formulations significantly (p<0.01) reduced the wound area. Ointment of 6 % w/w has shown better results than 2 and 4 % w/w. These results were compared to that of the standard framycetin. Poly-herbal formulation-1, poly-herbal formulation-2 and poly-herbal formulation-3 were prepared and used at doses of 100, 300 and 500 mg/kg to determine antiinflammatory activity. All poly-herbal formulations significantly (p<0.01) inhibited formalin-induced rat paw edema. Poly-herbal formulation-3 displayed greater inhibition than poly-herbal formulations 1 and 2. These results were comparable to that of the standard diclofenac. Present work and previous studies on poly-herbal formulations corroborates that these are safer and effective in treating inflammation and wounds.

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