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Exploration of cold extrusion for the preparation of enteric minitablets of isoniazid

Author(s): MC Gohel, KG Sarvaiya
Department of Pharmaceutics, L. M. College of Pharmacy, Ahmedabad-380009, India

Correspondence Address:
M C Gohel Department of Pharmaceutics, L. M. College of Pharmacy, Ahmedabad-380009 India E-mail: [email protected]

The objective of the present work was to formulate the enteric minitablets of isoniazid by cold extrusion method. The minitablets were prepared using isoniazid, hydroxylpropylmethylcellulose phthalate and dibasic calcium phosphate. The minitablets were coated using hydroxypropylmethylcellulose phthalate. Full factorial design was adopted to optimize the formulation. The minitablets showed good flow and acceptable friability. The drug release was resisted in 0.1 N HCl for 2 h from the optimized batch. The optimized batch showed more than 90% of drug release in phosphate buffer in 15 min. Capsules containing rifampicin powder and enteric isoniazid minitablets showed complete drug release in acidic and alkaline media respectively. The process of cold extrusion appears to be an attractive alternative to by-pass the existing patents.

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