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Abstract

Expression and Gene Regulation Network of Ubiquitin Specific Peptidase 5 in Colorectal Cancer

Author(s): F. Xing and X. K. Hu*
Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China

Correspondence Address:
X. K. Hu, Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China, E-mail: h06425@hrbmu.edu.cn


Colorectal cancer is one of the most commonly occurred cancers, although deubiquitination enzymes are related to tumor, the work of ubiquitin specific peptidase 5 in colorectal cancer is still not fully elucidated. Ubiquitin specific peptidase 5 expressions and prognosis was evaluated by analyzing a public dataset from the cancer genome atlas, gene expression omnibus database and a literature review. The biological function of ubiquitin specific peptidase 5 was investigated by gene set enrichment analysis. Ubiquitin specific peptidase 5 interaction proteins were shown by biological general repository for interaction datasets. Ubiquitin specific peptidase 5 is highly expressed and might be potentially used as a diagnostic and prognostic biomarker in colorectal cancer. Functional network analysis suggested that ubiquitin specific peptidase 5 is associated with proteasome, ribosome, deoxyribonucleic acid replication, cell cycle, spliceosome, etc. We discovered the correlation of ubiquitin specific peptidase 5 with several cancer related kinases, E2F transcription factors family and micro ribonucleic acids. Additionally, we presented about the ubiquitin specific peptidase 5 interaction proteins through protein-protein interaction network. Our results revealed information about ubiquitin specific peptidase 5 expression and its potential regulatory networks in colorectal cancer.

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