Abstract
Facile Synthesis and Characterization of Some New 5-ethylidene-Thiazolidine-2,4-diones and their Antimicrobial Evaluation
Department of Chemistry, Uka Tarsadia University, Surat 394350, Gujarat, 1Department of Chemistry, Government Science College Vankal, Surat 394430, Gujarat, India
Correspondence Address:
1Department of Chemistry, Government Science College Vankal, Surat 394430, Gujarat, India, E-Mail: mahajandh@gmail.com
A series of novel 5-ethylidene-thiazolidine-2,4-diones derivatives were synthesized by the knoevenagel condensation of aromatic ketone and N-substituted thiazolidinedione-2,4-diones. Use of KAl(SO4)2•12(H2O) i.e. Alum for the reaction makes this synthesis facile because of the some advantageous impacts viz. nontoxicity, efficient catalytic ability and lower cost of alum. Substitution of arylidene moiety at the position 5 on the thiazolidine-2,4-diones nucleus was carried out in this facile approach. Synthesized derivatives were characterized using various analytical tools and antimicrobial evaluation thereof was performed against Gram-positive, Gram negative bacteria and a fungal strain. All synthesized compounds showed moderate to very good activity against the microorganisms that they were tested for.
