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Abstract
Formulation and evaluation of trimetazidine dihydrochloride extended release tablets by melt congealing method
Author(s): SD Javeer, Reshma Pandit, SP Jain, Purnima Amin
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Pareikh Marg, Matunga, Mumbai - 400 019, India
Correspondence Address:
Purnima Amin Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Pareikh Marg, Matunga, Mumbai - 400 019 India E-mail: dramin@vsnl.net
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Pareikh Marg, Matunga, Mumbai - 400 019, India
Correspondence Address:
Purnima Amin Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Pareikh Marg, Matunga, Mumbai - 400 019 India E-mail: dramin@vsnl.net
Trimetazidine dihydrochloride, a cellular antiischemic agent indicated in the management and prophylaxis of angina pectoris is given as 20 mg thrice daily in the conventional dosage regimen. The purpose of the present study was to formulate and evaluate twice a day extended release tablets containing 30 mg trimetazidine dihydrochloride. The method developed to formulate these extended release tablets was melt congealing followed by wet granulation which exhibited uniform sustained release action and overcame the drawbacks of multidosing. The formulation was developed with Methocel® K100M and stearic acid as release retardant.
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