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Abstract
High performance thin layer chromatographic method for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride
Author(s): SS Chitlange1, DM Sakarkar2, SB Wankhede1, SG Wadodkar3
1Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune- 411 018, India 2S. N. Institute of Pharmacy, Pusad-445 204, India 3Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur-441 002, India
Correspondence Address:
S S Chitlange Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune- 411 018 India E-mail: Sohanchitlange@rediffmail.com
1Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune- 411 018, India 2S. N. Institute of Pharmacy, Pusad-445 204, India 3Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur-441 002, India
Correspondence Address:
S S Chitlange Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune- 411 018 India E-mail: Sohanchitlange@rediffmail.com
High performance thin layer chromatographic method is developed for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride in tablets. Silica gel 60F 254 plates were used as stationary phase and t.butanol: ethyl acetate: glacial acetic acid: water (7:4:2:2 v/v) as mobile phase. Wavelength selected for analysis was 254 nm. Percent estimation of ibuprofen and pseudoephedrine hydrochloride was found to be 99.56% and 98.77%, respectively. Percent recovery for both the drugs was found in the range of 98.27% to 100.91%, respectively.
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