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Abstract

High performance thin layer chromatographic method for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride

Author(s): SS Chitlange1, DM Sakarkar2, SB Wankhede1, SG Wadodkar3
1Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune- 411 018, India 2S. N. Institute of Pharmacy, Pusad-445 204, India 3Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur-441 002, India

Correspondence Address:
S S Chitlange Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune- 411 018 India E-mail: [email protected]


High performance thin layer chromatographic method is developed for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride in tablets. Silica gel 60F 254 plates were used as stationary phase and t.butanol: ethyl acetate: glacial acetic acid: water (7:4:2:2 v/v) as mobile phase. Wavelength selected for analysis was 254 nm. Percent estimation of ibuprofen and pseudoephedrine hydrochloride was found to be 99.56% and 98.77%, respectively. Percent recovery for both the drugs was found in the range of 98.27% to 100.91%, respectively.

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