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In silico Antidiabetic Screening of Borapetoside C, Cordifolioside A and Magnoflorine

Author(s): P. Khanal*, B. K. Mandar, B. M. Patil and K. K. Hullatti1
Department of Pharmacology and Toxicology, 1Department of Pharmacognosy, KLE College of Pharmacy, Belagavi-590 010, India

Correspondence Address:
Department of Pharmacology and Toxicology, KLE College of Pharmacy, Belagavi-590 010, India, E-mail:

The current study was aimed to screen borapetoside C, cordifolioside A, and magnofl orine against targets that are involved in the pathogenesis of type 2 diabetes mellitus. All active compounds were retrieved from PubChem database and protein molecules were downloaded from Protein Data Bank. Each protein was prepared using Discovery studio, and the binding pocket was predicted using castP. Each ligand was docked against the target proteins using AutoDock 4.0 Drug-likeness, toxicity and probable antidiabetic activity of each compound were also predicted. Among the three phytoconstituents, magnofl orine scored highest druglikeness score and also predicted to be a potent antidiabetic molecule. Comparisons were made with two clinically approved antidiabetic drugs i.e. sitagliptin and repaglinide.

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Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report