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Immunomodulating Properties of Polygonum multiflorum Extracts on Cyclophosphamide-induced Immunosuppression Model

Author(s): H. J. Yang, M. J. Kim, H. J. Kang, H. Y. Lee1, Y. M. Park1, Y. H. Lee1, Y. G. Kang1, G. P. Hwa1, Y. S. Kang2, Y. M. Jung2, N. K. Lee3*, and K-H. Park4*
Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seungnam, Kyunggi 13539, 1Invivo Co. Ltd., 460, Iksandae-ro, Iksan, Jeonbuk 54538, 2Jiri mountain hasuo farming union corporation, 2605-63 Chinhwankyeong-ro, Geumseo-myeon, Sancheong, Gyeongnam, 52215, 3Department of Oriental Medicine Resources, Chonbuk National University, Iksan 54596, Korea, 4Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, 62271, Korea

Correspondence Address:
Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, 62271, Korea, E-mail:

The objective of the present study was to investigate the immunomodulating property of Polygonum multiflorum extracts using various in vitro and in vivo tests. In this study, Polygonum multiflorum extracts were shown to exhibit immunomodulating activities such as cytokine production in normal rat splenocyte and cyclophosphamide-induced immunosuppression model. The immunostimulant effects of Polygonum multiflorum extracts were further tested for various immunological markers. Polygonum multiflorum extracts significantly enhanced cytokines production activity in rat splenocyte. Consistently oral administration of Polygonum multiflorum extracts enhanced blood cytokine production and ameliorated spleen damage in cyclophosphamide immunosuppressed rat. In conclusion, the present investigation revealed that Polygonum multiflorum extracts possessed immunomodulating and immunostimulating properties.

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