Abstract

The green synthesis of nanoparticles is gaining popularity due to its environmentally friendly, non-toxic and cost-effective properties. The distribution used of microproducts into the world are raised the concern of their implications on public health, in particular, Perfluorooctanoic acid which are variety used in a range of industries and consumer products as surfactants. The current study focused on the effects of biologically synthesized silver nanoparticle extract from Aloe vera (Aloe vera- silver nanoparticles) on genotoxicity induced by Perfluorooctanoic acid. After the treatment period, the rats were euthanized, blood and liver samples were collected for biochemical, histological and genetic analysis. The results indicate a notable increase in oxidative stress markers (glutathione, superoxide dismutase, catalase and lipid peroxidation), associated with a pathological change in the liver cells and deoxyribonucleic acid damage following treatment with Perfluorooctanoic acid. In contrast, treatment with silver nanoparticle extract of Aloe vera gel significantly mitigated oxidative stress, enhanced liver function and decreased deoxyribonucleic acid strand br eaks.