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Improvement of inhalation profile of DPI formulations by carrier treatment with magnesium stearate

Author(s): Shruti Hazare, Mala Menon
Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai-400 098, India

Correspondence Address:
Shruti Hazare Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai-400 098 India [email protected]

In the present study, the applicability of magnesium stearate-treated lactose carrier particles was evaluated to improve the inhalation performance of catalase microspheres. Bovine liver catalase microspheres with different stabilizers were prepared by spray drying. For the surface modification, lactose products were treated with 1 and 2% magnesium stearate by manual mixing and gently passed through a # 60 size mesh. The results revealed that magnesium stearate can be applied as a performance improver for catalase microsphere based DPI formulations.

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