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Abstract

Nanosponges: A Brief Review

Author(s): C. Surushe*, J. Thake1, M. Karpe and V. Kadam
Bharati Vidyapeeth???s College of Pharmacy, Navi Mumbai, Maharashtra 400614, 1S.M.B.T College of Pharmacy, Nashik, Maharashtra 422403, India

Correspondence Address:
C. Surushe, Bharati Vidyapeeth???s College of Pharmacy, Navi Mumbai, Maharashtra 400614, India, E-mail: chaitanyasurushe31@gmail.com


Nanotechnology advancements have resulted in the creation of tailored medicine delivery systems. Because of its potential to address a wide range of unexplored difficulties, nanotechnology-based medication delivery systems are acquiring significant relevance in the modern day. Nanosponges are microscopic sponges the size of a virus (250 nm-1 μm) having cavities that may be filled with a wide range of hydrophobic and hydrophilic medicines also overcome issues such as medication toxicity and low absorption. Nanosponges are solid porous particles with the ability to load medications and other actives into their nanocavity; they can be manufactured in oral, topical, parenteral or inhalation dosage forms. Crosslinking cyclodextrin with carbonyl or di-carboxylate can be used to create nanosponges (Crosslinkers). Another key features of nanosponges includes their aqueous solubility, which allows them to be used efficiently for medications with low solubility. Nanosponges can also be used as a vehicle for enzymes, proteins, vaccines and antibodies.

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