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Novel anthraquinone-based derivatives as potent inhibitors for receptor tyrosine kinases

Author(s): M Stasevych1, V Zvarych1, V Lunin1, T Halenova2, O Savchuk2, O Dudchak1, M Vovk3, V Novikov1
1Lviv Polytechnic National University, S. Bandera Street 12, Lviv-13, 79013, Ukraine 2Educational and Scientific Centre, Institute of Biology, Taras Shevchenko National University of Kyiv, Volodymyrska Street 64/13, Kyiv 01601, Ukraine 3Institute of Organic Chemistry of NASU, Murmanska Street 5, 02660 Kyiv-94, Ukraine

Correspondence Address:
M Stasevych Lviv Polytechnic National University, S. Bandera Street 12, Lviv-13, 79013 Ukraine E-mail: [email protected]

The influence of new derivatives of 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity of membrane-associated tyrosine kinases was investigated. Inhibitors of protein tyrosine kinase activity of the membrane fraction, as promising agents to search for new potential anticancer agents among the studied compounds, were discovered.

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Citations : 53647

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