Abstract

To investigate the expression of lymphocyte cytoplasmic protein 1 in plasma and tumor tissues of patients with gastric cancer and to analyze the correlation between lymphocyte cytoplasmic protein 1 and clinicopathological indexes and its effect on tumor immune infiltration. The expression of lymphocyte cytoplasmic protein 1 in plasma samples of 61 patients with gastric cancer who underwent surgery from December 2019 to December 2020 was detected by enzyme-linked immunosorbent assay. The expression of lymphocyte cytoplasmic protein 1 was detected by immunohistochemical staining and western blot. To study the correlation between pathology and lymphocyte cytoplasmic protein 1 expression in gastric cancer and the effect of lymphocyte cytoplasmic protein 1 expression on tumor immune infiltration. The expression of lymphocyte cytoplasmic protein 1 was closely related to the tumor size, differentiation, lymph node metastasis, tumor, nodes and metastases stage and depth of invasion of gastric cancer (p<0.05). After the expression of lymphocyte cytoplasmic protein 1, the migration and infiltration ability of gastric cancer MKN45 cells and BGC823 cells were improved (p<0.05). The expression of lymphocyte cytoplasmic protein 1 is closely related to the pathology of gastric cancer and the high expression of lymphocyte cytoplasmic protein 1 can significantly enhance the immune infiltration ability of gastric cancer and then has the potential of drug therapeutic targets.