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Phytochemicals: A Novel Approach for the Management of Coronavirus Disease 2019

Author(s): R. S. Shivatare*, R. Musale, N. K. Bhutale, S. M. Kewatkar, H. L. Tare, Vibhavari Chatur, A. N. Khatawakar and D. S. Suryavanshi
Department of Pharmacy, Jagdishprasad Jhabarwal Tibervala University, Jhunjhunu, Rajasthan 333001, 1Department of Pharmacognosy, Rajarshi Shahu College of Pharmacy, Buldana, Maharashtra 443001, 2Department of Pharmacy, Sharadchandra Pawar College of Pharmacy, Otur, Maharashtra 412409, 3Department of Pharmaceutics, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Pune, Maharashtra 411019, 4Department of Pharmacy, Anuradha College of Pharmacy, Chikhli, Maharashtra 443201, 5Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Pune, Maharashtra 411044, India

Correspondence Address:
R. S. Shivatare, Department of Pharmacy, Jagdishprasad Jhabarwal Tibervala University, Jhunjhunu, Rajasthan 333001, India, E-mail:

The severe acute respiratory syndrome coronavirus 2, formerly known as 2019 novel coronavirus, the causative pathogen of coronavirus disease 2019 is a major source of disaster in the 21st century. In the second meeting of the Emergency Committee, the World Health Organization declared that coronavirus disease 2019 is a “public-health emergency of international concern” on 30 January, 2020. Coronavirus is transmitted via airborne droplets from human to human or human to animal. Through membrane angiotensin-converting enzyme 2 exopeptidase receptor coronavirus enters in human cell. For the treatment of this sudden and lethal disease during coronavirus disease 2019, there are no specific anti-virus drugs or vaccines. Still, the development of these medicines will take months, even years. Currently there is need of supportive care and non-specific treatment to improve the symptoms of coronavirus disease 2019 infected patient. For this specific indication, rapid performance of herbal medicine or phytochemicals can contribute as an alternative measure. Phytochemicals are a powerful group of chemicals that are derived from plants origin hence causing fewer side effects because of less use of additives, preservatives or excipients. Hence, this review will focus on some phytochemicals which may control and prevent severe acute respiratory syndrome coronavirus 2. Further, the existing healing options, drugs accessible, ongoing trials and current diagnostics to treat severe acute respiratory syndrome coronavirus 2 have been discussed. We suggested phytochemicals extracted from herbal plants are potential novel therapeutic approaches, completely targeting severe acute respiratory syndrome coronavirus 2 and its pathways.

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